I don't see how what you're describing can be any disadvantage, but whether it's an advantage is open to question.
I do suspect that if the tow vehicle is a pickup and the trailer body is not wider than the pickup, then anything you do won't make much difference.
The one exception may be if the trailer has substantially less ground clearance than the tow vehicle - in effect the underside of the trailer becomes the one place where it projects beyond the tow vehicle. Posters on the Fiberglass RV board seem to think this matters. Personally I am unconvinced.
Must go - atoms to split, diseases to cure, etc, etc
Andrew